Is running indicated for patient with haemophilia? A narrative review

Details

Supervisors

Nguyen, Anh Phong

Faculty

Faculté des sciences de la motricité

Degree label

Master [120] en sciences de la motricité, orientation générale, à finalité spécialisée: kinésithérapie musculo-squelettique

Abstract

Introduction: Haemophilia is an inherited hematological disorder caused by a partial or complete deficiency of clotting factor VII or IX. The disease is characterized by spontaneous bleeding affecting the musculoskeletal system, which induce severe joint damage and muscle complications. Nowadays, patients with haemophilia (PWH) but also healthy individuals are known to have a relatively negative image of running on joint health. Aim: The purpose of this narrative review is to describe the impact of running on joint cartilage on PWH, patients with osteoarthritis symptoms, patients with a hip or knee prosthesis but also on healthy individuals. Furthermore, this review intends to provide running recommendations for these populations. Methods: Three electronic databases were searched, along with citations in eligible articles. A total of 284 articles were read and summarized. All included articles were about the relationship between running and health cartilage, osteoarthritis, prothesis or haemophilia. Results: Immediate effects, i.e., up to one hour demonstrated a decrease in knee joint cartilage volume as well as an increase of biochemical markers indicating a degradation of cartilage volume. However, these effects seem to be reversible more than one hour after running. Moreover, there is no evidence of damage to arthroplasty after hip and knee surgery in several years of follow-up. Conclusion: There is a misperception in healthcare practitioners’ recommendations. In the long-term, running also appears to improve joint health and activity limitations in PWH. Running should be encouraged in patients with haemophilia, osteoarthritis patients or general population. Indeed, the positive effects of running on a healthy joint are well documented. However, the impact of running after a total hip or knee arthroplasty should be further studied in the future to provide a better running guideline.