Tackling the diffusion problem of contrast-enhanced microCT imaging of tissues: an ultrasound approach

Details

Supervisors

Kerckhofs, Greet

Faculty

Ecole polytechnique de Louvain

Degree label

Master [120] : ingénieur civil biomédical, à finalité spécialisée

Abstract

enContrast-enhanced computed tomography (CECT) is a promising technique for three-dimensional imaging of soft biological tissues, but its development remains limited by the slow and heterogeneous diffusion of CESAs within dense extracellular matrices. In this context, this master’s thesis investigated the respective effects of ultrasound exposure and cyclic elevated temperature on the diffusion of Hf-WD 1:2 polyoxometalate (POM) within porcine aortic tissues. To achieve this objective, a new experimental platform capable of independently regulating ultrasound activation cycles and bath temperature was developed and experimentally validated.