Creation of a platform to study the impact of cell membrane surface tension on virus infectivity

Sauvenière, Théophile
(2025)

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Sauvenière, Théophile_04611900_2025.pdf
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Supervisors
Alsteens, David
Faculty
Faculté des bioingénieurs
Degree label
Master [120] : bioingénieur en sciences agronomiques, à finalité spécialisée
Abstract
enCell membrane mechanical properties like surface tension, stiffness and elasticity are now seen as playing a vital role in regulating cell behaviour, especially during processes like viral entry where the membrane is remodelled. The objective of this dissertation was to formulate and substantiate a pioneering experimental framework integrating two-dimensional micropatterning and atomic force microscopy (AFM), with a view to investigating how geometric limitations regulate membrane mechanics and possibly impact the initial phases of viral infection. Three epithelial cell lines, HeLa, Caco-2 and MDCK, were used ...