Vers une prise en charge intégrative de l’insulinorésistance : entre science et mode de vie

Details

Supervisors

Kirschvink, Nathalie

Faculty

Faculté de pharmacie et des sciences biomédicales

Degree label

Master [120] en sciences pharmaceutiques, à finalité spécialisée

Abstract

enIn a context where insulin resistance (IR) is common but often silent, it is now emerging as a public health issue, with its prevalence increasing in parallel with the rise in obesity and type 2 diabetes (DT2). This trend is part of a broader societal context, linked in part to changes in our diet (added sugars, fast food) and lifestyles (sedentary habits, stress, insufficient sleep), which are increasingly affecting our metabolic balance. This bibliographic review aims to answer the following question : « Can a non- pharmacological approach improve insulin sensitivity with efficacy comparable to pharmacological treatments ? » The approach is based first on an in-depth understanding of IR, then on an analysis of therapeutic options, both pharmacological and non-pharmacological. This analysis is based on scientific sources (reference works, articles) and a critical reading of comparative studies in order to compare the effectiveness of different approaches. The results converge on one key idea : in the early stages (IR/prediabetes), lifestyle is the most robust foundation, and certain medications mainly provide an additional benefit that is often modest, depending on the comparator, tolerance, and adherence. The difficulty then lies in the long-term adoption of healthy lifestyle measures and any necessary treatments. In a patient-centered « one health » approach, IR is understood as a systemic imbalance : the goal is to act on the body as a whole through coordinated actions. In this context, the role of the pharmacist goes beyond dispensing: it consists of educating and supporting the patient, making the pharmacy a key player in prevention and follow-up, complementing the role of the doctor.