How topical application of capsaicin, menthol and cinnamaldehyde affects the perception of cool, warm, noxious cold and noxious warm for healthy people.

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Supervisors: Mouraux, André
Faculty: Faculté des sciences de la motricité
Degree label: Master [60] en kinésithérapie et réadaptation
Abstract: Objective: This study purpose is to better understand the impact of topical application of 3 active molecules (L-menthol, capsaicin and cinnamaldehyde) on the individual perception of innocuous and noxious cold and warm. Method:12 subjects, tested three times (each molecule compared to control ethanol) with one week between tests. Patches were applied for ten minutes with control of spontaneous perception (VAS) at 5', 10', and 15' post-application. Two types of tests were practiced: Cold (-5°C to baseline) and heat (60°C) repetitive stimulations (30) and thresholds measurements (cool, warm, noxious cold and noxious warm). The stimuli were applied on the central third of the volar forearm. Results: Results are unfortunately insignificant for the most part and we weren't able to show the influence of these molecules. An effect of "time/repetition" has been shown during the repetitive stimulation sets but with no proof of substance impact. Conclusion: A very low concentration of product and a too long experimental design are two main explanation of the lack of significant results. More specific investigation and modification of the design might help to find the precise impact of L-menthol, capsaicin and cinnamaldehyde.