Apports de l'acide bempédoïque dans l'arsenal thérapeutique des hypocholestérolémiants

Details

Supervisors

Beauloye, Christophe

Faculty

Faculté de pharmacie et des sciences biomédicales

Degree label

Master [120] en sciences pharmaceutiques, à finalité spécialisée

Abstract

enBackground : The management of people requiring lipid-lowering therapy can be improved. Many patients do not reach the guidelines value for LDL-cholesterol. Some others are uncapable or unwilling to take statins, the first molecules considered. Bempedoic acid is a new active ingredient recently marketed in Belgium, which may help practitioners et patients to deal with these two problems. Method and main objectives : In this thesis, the interest is first focused on the pharmacological characterisation of bempedoic acid. Its specificities are presented and compared with those of the main molecules used for the sames indications in the country. Secondly, the work is devoted to a detailed analysis of the studies preceding the marketing authorization and of a clinical trial in progress evaluating its potential impact on strong criteria. All the information gathered allows to determine the interests of bempedoic acid as well as its disadvantages. The thesis also discusses about the potential positioning among the cholesterol-lowering agents. In conclusion, a reasoned position statement is proposed based on currently available data. Conclusion : Bempedoic acid is an innovative molecule with as many strengths as weaknesses. More precise data concerning its efficacy on strong criteria are not available yet. Until then, it is necessary to carefully select the patients to be treated and to be cautious about the side effects of the active ingredient.