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THE SUBTHALAMIC NUCLEUS AS A POTENTIAL NEURAL DRIVER FOR MOTOR INHIBITION DURING ACTION PREPARATION ?

Cakiroglu, Inci
(2021)

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Cakiroglu_Inci_76091300_2020-2021.pdf
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Details

Supervisors
Duque, Julie
Faculty
Faculté de pharmacie et des sciences biomédicales
Degree label
Master [120] en sciences biomédicales, à finalité approfondie
Abstract
Recent Transcranial Magnetic Stimulation (TMS) studies in humans have highlighted a decrease in corticospinal excitability during action preparation. This phenomenon, called "preparatory suppression", can be assessed by applying TMS over the primary motor cortex during Instructed-Delay Choice Reaction Time Tasks, thus eliciting motor evoked potentials (MEPs) in contralateral hand muscles. This phenomenon, although highly reproducible, is still under investigation as its neural origins haven’t been elucidated yet. Potential actors in line of sight are the basal ganglia, in particular the subthalamic nucleus (STN), as they are known to be able to exert a strong inhibitory influence on the primary motor cortex. Therefore, we wanted to evaluate the possible contribution of the STN to preparatory suppression by measuring MEP amplitudes during action preparation in Parkinson’s Disease (PD) patients treated with bilateral Deep Brain Stimulation (DBS) to the STN.