Traitement de l'hypertension artérielle pulmonaire : Etat des lieux et nouvelles cibles thérapeutiques

Rhallab, Meriam
(2021)

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Rhallab_Meriam_63471600_2020-2021.pdf
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Details

Supervisors
Dessy, Chantal
Faculty
Faculté de pharmacie et des sciences biomédicales
Degree label
Master [120] en sciences pharmaceutiques
Abstract
enPulmonary arterial hypertension is a rare but fatal disease, a characteristic that places this pathology at the top of the list of concerns in the field of pulmonology. The complex pathophysiology and variations in responses to clinical treatments make it a difficult disease to treat. Current treatments mainly relieve the symptoms but do not prevent the development of the pathology. These treatments consist mainly in pulmonary vasodilators, with a limited effect on vascular remodeling. The objective of this work, based on a literature search of clinical studies, reviews and meta-analyzes, is to summarize the main effects of treatments for pulmonary hypertension used in clinical practice. A second objective is to show the evolution of research towards a more complete management of the pathology. Recent discoveries on the pathophysiology of the disease make it possible to define new potential targets.