L'utilisation des inhibiteurs sélectifs de la recapture de la sérotonine dans la prise en charge de la dépression chez la femme enceinte

Details

Supervisors

Hermans, Emmanuel

Faculty

Faculté de pharmacie et des sciences biomédicales

Degree label

Master [120] en sciences pharmaceutiques

Abstract

enThe use of antidepressants during pregnancy remains controversial. Nevertheless, depression occurring during the gestation period is, contrary to popular believes, a relatively common pathology. For this reason, it is essential to consider the safety of the antidepressant medication taking and more specifically the use of selective serotonin reuptake inhibitors in pregnant patients. SSRIs are amongst the most frequently prescribed antidepressants to pregnant women but the available data on their benefits/risks balance remain relatively controversial and contradictory. However, it is essential for practitioners to have access to conclusive evidences regarding the initiation, continuation or interruption of antidepressant therapies during pregnancy. First, this thesis discusses the risks associated with an untreated antenatal depression and secondly, it looks at the consequences of taking SSRIs during the pregnancy period. It should be noted that it is still very difficult to distinguish the effects directly attributable to the underlying disease from those resulting from SSRI treatment. Finally, first-line molecules, adequate dosages, the safety of SSRIs during breastfeeding, etc are analysed from a more clinical point of view. However, due to the lack of studies on the subject, the data provided during this second part are relatively trivial.