La résolution de la réponse inflammatoire dans la mucoviscidose : Le rôle des résolvines

Details

Supervisors

Yussuff A. M., Islamiyyat

Faculty

Faculté de pharmacie et des sciences biomédicales

Degree label

Master [60] en sciences biomédicales

Abstract

enCystic fibrosis is a recessive genetic disease caused by mutations in the CFTR (cystic fibrosis transmembrane regulator) gene, encoding the CFTR protein, a chloride channel. The dysfunction of the channel prevents the proper transport of ions, resulting in impaired mucociliary clearance, an environment conducive to infections and chronic inflammation. Ultimately, this results in lung destruction and respiratory failure. The inflammatory response is normally followed by a resolution phase that allows tissue repair and restoration of tissue homeostasis. This involves specialized pro-resolving mediators (SPMs), including resolvins, which are emerging as a promising resolution-targeted therapy, and their administration to cystic fibrosis patients would promote resolution of inflammation, pathogen elimination and tissue regeneration. This molecule would be a major advance in the treatment of cystic fibrosis. This thesis highlights the effects of inflammation on the lungs and the impact of resolvins on airway dysfunction.