Effects of food ingredients and stress on adiposity and gut microbiota-derived volatile compounds in diet-induced obese mice

Vander Borght, Alexia
(2026)

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Details

Supervisors
Delzenne, Nathalie M. ; Debier, Cathy
Faculty
Faculté des bioingénieurs
Degree label
Master [120] : bioingénieur en chimie et bioindustries, à finalité spécialisée
Abstract
enThis study examines how specific dietary components and stress impact the development of obesity in mice fed a Western diet. Two experimental studies examined the impact of gluten, carrageenan, marine collagen peptides (Naticol), and stress on body weight, adipose tissue growth, inflammation, and gut microbial metabolism. Adipocyte morphology was quantified using Adiposoft, inflammatory markers were measured by RT-qPCR, and fecal and cecal volatile organic compounds (VOCs) were analyzed using SIFT-MS. Overall, this study identifies κ-carrageenan as a factor that exacerbates metabolic alterations under a Western diet and suggests that SIFT-MS VOC analysis could be a tool for exploring gut dysbiosis.